Effects of exercise on cellular and tissue aging

source: https://www.aging-us.com/article/203051/pdf

ABSTRACT
The natural aging process is carried out by a progressive loss of homeostasis leading to a functional decline in
cells and tissues. The accumulation of these changes stem from a multifactorial process on which both external
(environmental and social) and internal (genetic and biological) risk factors contribute to the development of
adult chronic diseases, including type 2 diabetes mellitus (T2D). Strategies that can slow cellular aging include
changes in diet, lifestyle and drugs that modulate intracellular signaling. Exercise is a promising lifestyle
intervention that has shown antiaging effects by extending lifespan and healthspan through decreasing the
nine hallmarks of aging and age-associated inflammation. Herein, we review the effects of exercise to
attenuate aging from a clinical to a cellular level, listing its effects upon various tissues and systems as well as
its capacity to reverse many of the hallmarks of aging. Additionally, we suggest AMPK as a central regulator of
the cellular effects of exercise due to its integrative effects in different tissues. These concepts are especially
relevant in the setting of T2D, where cellular aging is accelerated and exercise can counteract these effects
through the reviewed antiaging mechanisms.

#health #saúde #exercise #exercicio #deporte #diabetes #heart #aging #envellecemento #science #paper #ciencia

(virtual) IBRD 👣 2021 - May 2nd

source: thebarefootrunners.org



The International Barefoot Running Day that we have come to know and love over its last ten editions has been cancelled. With #Coronavirus still raging in many parts of the world and with countries everywhere in various stages of #lockdown, bringing people together physically in celebration of barefoot running would not be helpful (or, in many cases, legal). But that doesn’t mean that #barefoot #running (or #walking, #hiking, #climbing, whatever) stops. Connecting ourselves to the #earth, to #nature and to our primal selves is an incredibly important act, offering us immense physical and mental health benefits. With the world in turmoil and our overall wellbeing under unaccustomed stress, it’s never been more important to kick off our shoes and get out there (safely and responsibly).

So this year, International Barefoot Running Day is going Virtual. We invite people from all around the world to join us on Sunday the 2nd of May and free their feet! Wherever it is safe and legal to do so – in your home, garden, park, street, or local wilderness – leave your shoes behind and enjoy life barefoot. Tell your friends and family too – everyone is welcome – and let us know what you get up to. We’d love to gather your stories, pictures and videos for future posts here in the #IBRD Forum and on our social media channels, so send us your contributions to barefoot.runners.uk@gmail.com or use the hashtags #ibrd2021 and #barefootrunnerssociety on your social media posts.

Who knows - perhaps we can create the best International Barefoot Running Day yet, despite (or even because of!) the adversity we are all facing? Go Barefoot! Go Safely!

#barefootrunning #running #health